COMPARE-UF is a nationwide registry of women with uterine fibroids that hopes to answer questions about the outcomes of different treatment options.
Each participant will make treatment decisions with her personal doctor, and then share information about her current and past experiences with her fibroids, including how fibroids have impacted her quality of her life.

View the COMPARE-UF Data Collection Summary to see the information that will be asked of participants and obtained from medical records.

The Duke Clinical Research Institute (DCRI) of the Duke University Medical Center in Durham, NC serves as the Research Data and Coordinating Center (RDCC). Dr. Evan Myers is the Principal Investigator of the COMPARE-UF Registry.

How did we get here?

Uterine fibroid research interest by the Agency for Healthcare Research and Quality (AHRQ) has been ongoing since 1999.

1999-2000 Literature Review

AHRQ-funded systematic literature review by on management of fibroids
Result: almost no data to help patients make decisions. Only definitive conclusion was that hysterectomy is inappropriate for women who wish to retain fertility

2000–2005 Study of Uterine Artery Embolization

Society of Interventional Radiologists, with funding from AHRQ, FDA, and industry, enrolls over 3000 women undergoing uterine artery embolization (UAE), with up to 3 years follow-up by the Duke Clinical Research Institute (DCRI).

2007 Update to Literature Review

AHRQ-funded update on systematic review performed by RTI International.

2010–2011 Priorities Set

AHRQ-funded multi-stakeholder conference for priorities for comparative effectiveness research for fibroids.

2012 Application for Funding

Outcome applied for PCORI funding for analysis of private claims/EMR data, focused primarily on recurrence of symptoms/need for additional treatment.


2013 PCORI/Stakeholder Conference



PCORI announced $20 million for registry to be administered by AHRQ.

2013–2014 Request for Application

The Requests for Applications (RFA) timeline

September 30, 2013: RFA released
December 16, 2013: Proposal (paper) submitted
February 25, 2014: Score received (28)
March 5, 2014: Summary Statement
April 27, 2014: Response to reviewers, AHRQ/PCORI questions
May 2014: Updated response
July 2014: Response to second set of questions
September 2014: Response to administrative questions
September 30, 2014: Notice of grant award (NoGA)

2015 - Registry Enrollment Begins

First patients enrolled in the registry in December 2015.