For Healthcare Professionals

How can I refer my patients to COMPARE-UF?

Will my patient continue to be seen my practice?

I'm interested in using the COMPARE-UF data collection forms. Whom should I contact for permission?

Can my institution become a clinical site for COMPARE-UF, or can I participate in another way?


References for Professionals


The journal Menopause has published the results of a study that found hysterectomy is associated with an increased long-term risk of cardiovascular and metabolic conditions, especially in women who undergo the procedure at age 35 or younger.

The Evidence-based Practice Center Program at the Agency for Healthcare Research and Quality has published an evidence review on Management of Uterine Fibroids. The purpose of the review was to examine the treatment effectiveness and the risk of leiomyosarcoma (LMS) in women with fibroids.

Uterine fibroids were the focus of three articles published by COMPARE-UF collaborators in the November 2017 (Volume 130, Issue 5) Obstetrics and Gynecology (aka The Green Journal), the official publication of the American College of Obstetricians and Gynecologists (ACOG):

A comparison of the effectiveness of common uterine fibroid procedures (full text available): pp. 1047–1056, doi: 10.1097/AOG.0000000000002331.

An evaluation of changes in surgical practice for uterine fibroids after the U.S. Food and Drug Administration discourages common procedure: pp. 1057–1063, doi: 10.1097/AOG.0000000000002309

A review of 45 years of studies finds no link between uterine fibroids and spontaneous abortion: pp. 1065–1072, doi: 10.1097/AOG.0000000000002313

Epidemiology of uterine fibroids: a systematic review published in BJOG An International Journal of Obstetrics and Gynaecology May 13, 2017 identified 12 risk factors that play an important role in uterine fibroid (UF) epidemiology. The UF risk factor with the strongest evidence is black race. High-quality prospective observational data are needed to improve our understanding of UF epidemiology, and thus its aetiology and optimal management.

The June 23, 2016 issue of Nature provides a disease primer of uterine fibroids including a thorough review of the pathogenisis, pathophysiology, current treatments, and expected innovations.

Clinical OB and GYNThe March 2016 issue of Clinical Obstetrics and Gynecology focuses on the Modern Management of Fibroids. Check your local medical library for access.



AHRQ Statistical Brief: Hysterectomies to treat uterine fibroids fell 20 percent from 2005 to 2013 The Healthcare Cost and Utilization Project (HCUP) Statistical Briefs provide health care statistics on hospital inpatient stays, emergency department visits, and ambulatory surgeries. Topics include medical conditions treated, procedures performed, patient populations served, and quality of care. Information is presented in tables and figures, accompanied by explanatory text and are available on the HCUP website.

Read a comprehensive review of diagnostic strategies and treatment options by Dr. Elizabeth Stewart, COMPARE-UF investigator at Mayo Clinic. New England Journal of Medicine - Clinical Practice article April 23, 2015 Prefer to listen? Download the MP3 podcast of the full text.

A Mechanism of Action Review Article by Serdar E. Bulun, M.D. in the New England Journal of Medicine focuses on uterine fibroids. N Engl J Med 2013; 369:1344-1355 October 3, 2013

Characterization of Uterine Leiomyomas by Whole-Genome Sequencing appears in the July 4, 2013 New England Journal of Medicine.  N Engl J Med 2013; 369:43-53