Fibroids and miscarriage – is there a link?

Results of a ten year study (Right From the Start) that enrolled over 5500 women concluded that there is no link between fibroids and miscarriage.

“Women with fibroids now have one less thing to worry about.” ~Katherine Hartmann, MD, PhD

Dr. Hartmann of Vanderbilt University Medical Center began the study hoping to determine which fibroids increase the risk of miscarriage. The common clinical assumption is that fibroids increase the risk of miscarriage, and determining which types of fibroids cause more risk could help decide surgical treatment. Surprisingly, the conclusion of the study is that there is no increased risk. The risk of miscarriage is ~11% for women with and without fibroids.

Watch the video that explains the results of the research

Watch the interview with the study’s lead author Katherine Hartmann, MD, PhD

Read the article in the American Journal of Epidemiology

Epidemiology of uterine fibroids: a systematic review

Read the complete article in BJOG An International Journal of Obstetrics and Gynaecology


Journal: BJOG An International Journal of Obstetrics and Gynaecology

Authors: EA Stewart, CL Cookson, RA Gandolfo, R Schulze-Rath

Year Published: 2017



Uterine fibroids (UFs) are the most common neoplasm affecting women that can cause significant morbidity and may adversely impact fertility.


To examine UF epidemiology and to evaluate the relative strengths of putative risk factors.

Search strategy

MEDLINE and Embase were searched for studies published in English between January 1995 and April 2015.

Selection criteria

Publications reporting relevant data from registries and other observational studies with over 1000 patients and single-centre studies with over 100 patients were selected.

Data collection and analysis

Data on UF incidence, prevalence and associated risk factors were extracted from 60 publications.

Main results

Wide ranges were reported in both UF incidence (217–3745 cases per 100 000 women-years) and prevalence (4.5–68.6%), depending on study populations and diagnostic methods. Black race was the only factor that was recurrently reported to increase UF risk, by two–threefold compared with white race. Eleven other factors affected UF risk to a magnitude similar to or greater than race. Age, premenopausal state, hypertension, family history, time since last birth, and food additive and soybean milk consumption increased UF risk; use of oral contraceptives or the injectable contraceptive depot medroxyprogesterone acetate, smoking in women with low body mass index and parity reduced UF risk.


We identified 12 risk factors that play an important role in UF epidemiology. The UF risk factor with the strongest evidence is black race. High-quality prospective observational data are needed to improve our understanding of UF epidemiology, and thus its aetiology and optimal management.

Comparing fibroid embolization and focused ultrasound – a randomized controlled trial

Periprocedural Outcomes Comparing Fibroid Embolization and Focused Ultrasound: a Randomized Controlled Trial and Comprehensive Cohort Analysis

Published in the American Journal of Obstetrics and Gynecology online 5 January 2017, this paper is a report of The Fibroid Interventions: Reducing Symptoms Today and Tomorrow (FIRSTT) study, the first randomized controlled trial to compare these two fibroid treatments. (NCT00995878,